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Bupropion is undoubtedly an example of an antidepressant with the amphetamine-like composition similar to ephedrine, and it is an NDRI. Its motion bears much more resemblance to amphetamine than to fluoxetine in that its Most important mode of therapeutic action entails norepinephrine also to a lesser degree dopamine, but In addition, it releases some serotonin from presynaptic clefts. It should not be used with ephedrine, as it might increase the chance of Uncomfortable side effects.

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